Unani Proprietary Medicine

Hamdard Safi Blood Purifier

Hamdard Safi Blood Purifier is Unani proprietary medicine used for blood detoxification and improving skin glow and complexion. Generally, its indications include its use in acne or pimples, boils, blemishes, dark spots, skin allergic conditions (urticaria) and skin rashes. It improves digestion and helps clearing the toxins from the digestive system. In addition to these benefits, it is helpful in the treatment of nosebleed, indigestion and other pitta conditions. It is manufactured by Hamdard Laboratories (WAQF), Ghaziabad, India.

Ingredients (Composition)

5 ml Safi Syrup contains aqueous extracts of following herbs:
Senna (Sanay Leaves) – Senna Alexandrina 160.45 mg
Turbud (Turpeth) – Ipomoea Turpethum 25.45 mg
Gulab Ke Phool 24.77 mg
Burada Sheesham – Dalbergia Sissoo 13.40 mg
Sandal Surkh (Red Sandal) – Pterocarpus Santalinus 11.36 mg
Gilo (Giloy or Guduchi) – Tinospora Cordifolia 14.09 mg
Harar (Haritaki) – Terminalia Chebula 22.04 mg
Narkachoor 11.36 mg
Chiraita 17.38 mg
Burge Kasaundi 13.40 mg
Mundi 15.45 mg
Nilkanthi 16.13 mg
Shahtra 22.72 mg
Kachnal 15.45 mg
Neem – Azadirachta Indica 19.43 mg
Burge Tulsi – Ocimum Sanctum 13.40 mg
Zarambad 11.36 mg
Darhald (Daruhaldi) – Berberis Aristata 9.43 mg
Chobchini (Chopchini) 11.36 mg
Post Keekar 42.84 mg
Sankhaholi 14.09 mg
Sarphoka 18.06 mg
Ushba Maghrabi 5.68 mg
Brahmi – Bacopa Monnieri 9.09 mg
Chaksu 9.09 mg
Bekh Kasni 9.09 mg
Unnab 11.36 mg
Recand Chini (extract) 22.72 mg
Qand Sadaid Q.S.
Shora Desi 227.27 mg
Milleh Firangi 1.250 grams

Most of ingredients are bitter in taste, which gives bitter taste to Safi.

Pharmacological Actions

Most of ingredients in Hamdard Safi are bitter and exert anti-inflammatory, antiviral, antimicrobial, anti-toxin and soothing action on the skin. It also contains senna, Turbud and Haritaki, which act as laxative and clear the digestive system. Most possible mechanism of action is detoxification, which starts from digestive system and goes up to the tissue level especially skin level. Most ingredients are helpful for releasing toxins from the body and modulate the digestive system and exert bitter action on the blood. The most of skin diseases occur due to toxins accumulation in the body according to Unani as well as Ayurvedic medicine, which may also be in the alimentary canal as well as in the blood including other tissues of the body. The release and excretion of the toxins from the body may improve the skin health and treat the skin diseases.

Medicinal Properties

According to ingredients analysis of Safi, it may have following medicinal properties:

  • Detoxifier
  • Anti-toxin
  • Anti-microbial
  • Anti-viral
  • Mild Laxative
  • Antipruritic
  • Anti-inflammatory
  • Natural Antacid
  • Antiulcerogenic
  • Antihyperlipidemic
  • Antioxidant
  • Carminative
  • Depurative (purifies blood)
  • Demulcent
  • Diuretic
  • Immunomodulatory
  • Digestive
  • Mild Antihemorrhagic (mainly due to Sheesham)

Ayurvedic Properties

The Safi formulation consists of many ingredients, which mainly acts on aggravated Pitta, Pitta Dosha associated with AMA (toxins) and increased or aggravated Kapha Dosha. Therefore, Safi is more likely to beneficial for people with increased or aggravated Pitta and Kapha Dosha.

Therapeutic Indications

Hamdard Safi blood purifier is indicated in following health conditions:

  • Blood Detoxification (due to bitter constituents)
  • Acne Vulgaris
  • Boils
  • Skin eruptions
  • Skin rashes
  • Blemishes
  • Pruritus (itching)
  • Epistaxis (nosebleed)
  • Indigestion and heartburn
  • Mild constipation
  • Skin allergies – urticaria
  • Measles (to diminish the red spots and burning sensation)

Safi also has effects on accumulated fats, so it checks the fat metabolism and reduces its accumulation, which ultimately helps keeping the body slim.

Benefits & Medicinal Uses

Hamdard Safi has effects on the blood and skin. It is likely to reduce the toxin accumulation in the blood and reduces their effects on the skin.

Acne Vulgaris

Hamdard Safi is widely used among youngsters and teenagers for the management of the acne vulgaris. Several ingredients in Safi have anti-inflammatory, antibacterial, and antimicrobial properties, which help to reduce inflammation in the dermal layer of the skin. Furthermore, Safi prevents bacterial infections within the acne and reduces pigmentation, which helps preventing scar formation. In acute cases, Safi should be taken in dosage of 2 teaspoons (10 ml) thrice daily for at least 4 weeks.


Hamdard Safi is also beneficial in blemish treatment. It alone can reduce blemishes and dark spots. According to ancient science, increased Pitta in the body may lead to blemishes, so the treatment should be that which pacify the increased Pitta Dosha in the body. Safi is an excellent solution for this. In blemishes, Safi gives positive results when used for at least 6 months on regular basis in dosage of 2 teaspoons twice daily.

Dosage & Administration

The general dosage of Hamdard Safi (blood purifier) is as follows.
Children 5 ml *
Adults 10 ml *
Maximum Possible Dosage Per Day (in divided doses)
* Twice a day with a cup of water
Best Time to Take: Preferably 30 to 60 minutes before meal or on empty stomach in the morning and before sleep at night

How to Take Safi

You can take Safi Syrup with a cup of water. Warm water is more preferable and helpful for enhancing the absorption of phytochemicals present in the Safi.

Safety Profile

The safety profile of Safi is not well established on scientific parameters through research studies.

Side Effects of Safi Syrup

The side effects of Hamdard Safi are unknown.

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Dr. Jagdev Singh

Dr. Jagdev Singh (B.A.M.S., M. Sc. in Medicinal Plants) is an Ayurvedic Practitioner and Herbalist. He has successfully treated thousands of patients with Ayurveda (including Herbal Ayurvedic Medicine and Ayurvedic Diet). Ayur Times is an initiative of his efforts to bring quality information on Indian Medicine with the highest level of relevancy and scientific evidence.


  1. I was told that there are very high levels for arsenic in this product. Canadian food agency said that there was more than 40 times the acceptance level of arsenic. Please clarify. Thank you very much.

    1. However, the ingredients listed on the label don’t include arsenic in any form. Processed Arsenic is used in a very few of Ayurvedic and Unani medicines. There might be two possibilities:

      1. The manufacturer might have included Arsenic in Safi before reporting and issuing a warning by Canadian Government. Now, they might have changed their formulation.

      2. There might be arsenic contamination in Safi.

      Ayush Department of Indian Government has also disallowed to export any product outside India that contains heavy metals including arsenic, mercury, and lead, but they have not banned this in India.

    1. Generally, you should eat light food that you can easily digest. Increase intake of fruits and vegetables. Avoid non-veg., frozen, spicy or oil, and stale food.

    1. It will depend on several factors. Generally, most people require it for 3 months.

  2. Can we use any external skin cleaning and pimple curing agents like Vicco and apply them overnight without any fear of any side effects while we are drinking Safi? Also Safi will solve pimple issues till what extent? I mean will we have pimples back after the stoppage if consumption of safi, if they will then till what extent they will be back and what shall we do in order to cure them?
    Please answer this questions.

  3. I am having acne these days and after three months I m going to get married.will safi help me.how many times should I consume?what is the best time?plz help

  4. You should ideally have it twice a day with warm water without skipping any dose. Even the bottle says adults should have 10ml daily and children should have 5ml. So please have 2 spoons a day one in morning before having anything and one at night before going to the bed. Your acne will get reduced to a greater extent. Also externally apply acne removal creams on your face without any fail.

  5. How to intake Safi?
    Is it one teaspoon in the morning and one at night or
    two in the morning and two at night?

  6. Sir i m using Safi for 15 days but my acne has been increased in numbers now what to do ?? Please help me out

    1. This reply is based on articles that I read online and what I have heard from my friends:
      Like any other acne wash/cream, depending on the response of the body to this new syrup, the acne/boil might increase and pimples might breakout temporarily for a day or two, but then after your skin will heal up faster and become smoother and will have more glow, and will be free of dead skin cells. In order to get rid of dead cells on body, Safi will pass (excrete) them off the skin.
      Drinking safi regularly for a month will purify blood and cleanse it of harmful chemicals.

  7. there is boil under my arm which keeps coming within 15 days and it is very painful will consumption of safi helps

  8. Iam started using safi i have pimples and marks on my face will it help to reduce ?
    and will it increase the pimples while using please suggest me because iam having my marraige in march.

  9. Can Safi cause constipation I use it for 2 days and my stomach is a little upset

  10. Hi, I am taking this and other product for weight loss, which clears my tummy out. It makes me have stomach cramps and have loose stool. Does Safi have these side effects? Can I still use Safi or will it be to much?

    1. In some people, Safi may cause loose stools and cramps due to the presence of senna leaves in it. You may need to stop it and consult a physician for alternatives.

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