5 Amazing Health Benefits of Muscadine Grapes (Vitis Rotundifolia)

Muscadine Grapes (Vitis Rotundifolia) are heart-friendly, low-calorie, and fiber-rich fruits. The cardioprotective, antihyperlipidemic and antioxidant activities of these grapes help to improve heart functions, reduce cholesterol, and prevent coronary artery disease and atherosclerosis. These grapes are also beneficial for hypertensive people, especially people also suffering from hyperlipidemia. They help to regulate blood pressure. Muscadines also enhance non-specific immunity and help to prevent several diseases. Overall, muscadines are healthy fruits.

Phytochemistry (Chemical Constituents)

Muscadine Grapes contain two major polyphenolic constituents Resveratrol and Quercetin. Resveratrol found in these grapes is 6 times more than common grapes. (1)

Gallic acid, catechin, and epicatechin are found seeds. 100 grams seeds contain around 1299.4 mg epicatechin, 558.4 mg catechin, and 6.9 mg gallic acid.

In muscadine skin, quercetin, ellagic acid, kaempferol, myricetin, and trans-resveratrol are found. 100 grams fresh muscadine skin contains: (2)

Ellagic acid16.5 mg
Myricetin8.4 mg
Quercetin1.8 mg
Kaempferol0.6 mg
Trans-resveratrol0.1 mg

Fruit pulp also contains resveratrol, quercetin, ellagic acid, kaempferol, myricetin, and trans-resveratrol.

Muscadine Grapes (Vitis Rotundifolia)
Muscadine Grapes (Vitis Rotundifolia)

Pharmacological Actions

The insoluble dietary fiber in muscadine grapes helps to improve bowel movement. It is responsible for its anti-constipation action.

Ellagic acid is a potent antioxidant found in these grapes. It inhibits oxidation and prevents cell damage.

Ellagic acid also inhibits the cancer cell growth and resveratrol blocks cell cycle of cancer cells. The antioxidant, anticancer, and chemoprevention actions of muscadines help to prevent cancer and stop the growth of cancer cells.

Resveratrol affects mitochondria. It prevents damage to mitochondria and repairs the damaged mitochondria. It helps to improve lifespan.

Medicinal Properties

Muscadine Grapes (Vitis Rotundifolia) has following medicinal properties.

  • Antioxidant
  • Antiaging
  • Cardioprotective
  • Antihyperlipidemic
  • Anti-atherogenic
  • Anti-ischemic
  • Anticancer
  • Chemoprevention
  • Mild antihypertensive
Muscadine Grapes Vine
Muscadine Grapes Vine

Muscadine Grapes Health Benefits

The Health Benefits of Muscadine Grapes are attributed to phytochemicals. Most of these chemical constituents (especially Resveratrol) of muscadines have cardioprotective, antihyperlipidemic, anti-ischemic, anti-thrombotic, anti-atherogenic and mild antihypertensive actions. Muscadines also have antioxidant and anti-aging properties. Muscadine skin has anticancer action and it is likely to prevent cancer. It can also beneficial to inhibit the growth of cancerous cells by inducing apoptosis. Let’s discuss the health benefits of Muscadine Grapes in details:


The phenolic content in Muscadine Grapes is responsible for the potent antioxidant activity. (2)

Due to potent antioxidant activities, these grapes help to prevent cell damage and delay aging. They also decrease the risk of inflammations and prevent heart diseases, memory loss and other chronic diseases.

Incomplete evacuation & Constipation

250 grams Muscadine grapes contains around 9.8 grams dietary fiber. (3)

These grapes are also a good source of insoluble fiber content that promotes bowel movement. People having trouble bowel movement or bowel irregularities and feel incomplete evacuation or suffer from chronic constipation can eat muscadine grapes on regular basis.


Muscadine grapes (Vitis Rotundifolia) have antioxidant, anti-inflammatory, and anticancer actions attributed to their high phenolic and flavonoid content. These phytochemicals inhibit the growth of cancer cells by inducing apoptosis and disrupting abnormal proliferation. (4, 5, 6, 7)

Primarily, ellagic acid and resveratrol are two major compounds found in muscadines that inhibit the growth of cancer cells and block the cancer cell proliferation.

The high dietary fiber in these grapes also helps to prevent colon cancer and gastrointestinal diseases.

Muscadine grape skin extract (MGSE) inhibits the cell growth in prostate cancer. This action is attributed to its antioxidant and antitumor activities. (7, 8)

In conclusion, Muscadine grapes can help to prevent cancer by various mechanisms. They may inhibit cancer cell growth and become beneficial for cancer patients, especially for people suffering from colorectal cancer or prostate cancer, according to present studies.

Anti-inflammatory Properties

The ethanol extract of Muscadine grape skin powder reported exhibiting anti-inflammatory properties. (9)

Eating Muscadine grapes can also help to prevent and reduce inflammation, edema, and risk of several inflammatory diseases. Phyto-constituents including resveratrol are mainly responsible for anti-inflammatory properties of these grapes.

The topical application of muscadine grape extracts also helps to reduce local inflammation. (10)

Helicobacter Pylori Infection

Muscadine grapes contain quercetin, which is effective against inflammation caused by Helicobacter pylori infection due to its anti-inflammatory potentials. However, it might not be effective for reducing the growth of Helicobacter pylori, but it can help to reduce and prevent inflammation caused by H. pylori infection. (11)

Muscadine Grapes (Vitis Rotundifolia)
Muscadine Grapes (Vitis Rotundifolia)

Muscadine Grape Seed Oil Benefits

Muscadine Grape Seed Oil is a rich source of tocotrienols. It contains significant amounts of alpha and gamma tocotrienol. These are unsaturated forms of Vitamin E. Vitamin E is made of tocotrienols and tocopherols.

Tocotrienols are known for several health benefits. Taking tocotrienols can help to prevent aging, Alzheimer’s diseases, atherosclerosis, diabetes, high cholesterol, stroke, cancer and kidney diseases.

Muscadine Grape Seed Oil also has anti-inflammatory and anti-adipogenic actions. It helps to reduce adipose inflammation. The adipose inflammation is linked to obesity and unnatural fat accumulation in the body. The inclusion of muscadine grape seed oil in diet can help to reduce weight. It prevents fat accumulation by delaying new fat formation. (12)

Muscadine Grapes (Vitis Rotundifolia)
Muscadine Grapes (Vitis Rotundifolia)

Safety Profile

Muscadine grapes (Vitis Rotundifolia) are likely safe when eaten in natural form. A research study suggested that Muscadine grape skin extract (MGSE) is also likely safe when used in dosage of 500 to 4000 mg. (13)

Side effects of Muscadine grapes

Muscadine grapes eaten in natural form are not likely to cause any side effects.

However, Muscadine grape skin extract (MGSE) is reported to have mild gastrointestinal side effects in some patients, that include: (13)

  1. Flatulence
  2. Soft stools
  3. Eructation

Further Readings

  1. Muscadine Grapes Nutrition

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Dr. Jagdev Singh

Dr. Jagdev Singh is a qualified Ayurvedic Practitioner and Herbalist with B.A.M.S. and M. Sc. in Medicinal Plants. He has a wealth of experience in using Ayurveda to treat patients, including the use of herbal medicine and personalized Ayurvedic diets. His passion for spreading accurate and scientific information about Ayurveda and Medicinal Plants led him to create Ayur Times, a trusted resource for those seeking reliable information on the topic. Through his dedicated work, Dr. Singh has helped thousands of patients find relief and improve their health with Ayurveda and Herbal Medicine.

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